What does "Route of Flight" denote in air navigation?

The term "Route of Flight" specifically refers to the path that an aircraft follows from its point of departure to its intended destination. This encompasses not just the straight line connecting these two points, but also any waypoints, airways, and specific navigation instructions that guide the aircraft during its journey. Understanding the route of flight is essential for ensuring proper navigation, safety, and compliance with air traffic control directives.

In the context of air navigation, the route is meticulously planned to ensure that it avoids hazards, complies with air traffic regulations, and is efficient in terms of distance and fuel consumption. Consequently, option C accurately captures the comprehensive nature of the term "Route of Flight" in aviation.